Osteoporosis Research Today is a free monthly online journal that collates and summarizes the latest research about Osteoporosis, including details on symptoms, treatment, prevention, causes.

New biocomposite [biphasic calcium phosphate/ poly-DL-lactide-co-glycolide/biostimulative agent] filler for reconstruction of bone tissue changed by osteoporosis.

Ignjatovic N, Ajdukovic Z, Uskokovic D

Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, Belgrade.

Biphasic calcium phosphate-poly-DL-lactide-co-glycolide composite biomaterial with and without biostimulative agents (protein-rich plasma or fibrin) was synthesised in the form suitable for reconstruction of bone defects. The composite used as filler was obtained by precipitation in solvent-non-solvent systems. The material, calcium phosphate granules covered by polymer, was characterised by wide-angle X-ray structural analysis, scanning electron microscopy, infrared spectroscopy and differential scanning calorimetry. Reparation of bone tissue damaged by osteoporosis was investigated in vivo on rats. The method applied enabled production of granules of calcium phosphate-poly-DL-lactide-co- glycolide composite biomaterial of average diameter 150-200 mum. Histological analysis confirmed recuperation of the alveolar bone, which osteoporosis-induced defects were repaired using composite biomaterial. By addition of biostimulative agents, intensity of osteogenesis increases accompanied by the formation of regular, new bone structure.

Published 20 June 2005 in J Mater Sci Mater Med, 16(7): 621-6.
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